hrp0092s10.1 | Brain development and sex: Is it Chromosomes or Hormones? | ESPE2019

Multifaceted Origins of Sex Differences in the Brain

Reinl Erin , McCarthy Margaret

Sex is one of the strongest biological factors influencing neural development, and yet our understanding of the molecular underpinnings of sexual differentiation is only just beginning. Just like the bipotential gonads, which only differentiate upon expression of SRY in XY males, the brain is also bipotential and differentiates due to a combination of genetic, epigenetic, environmental, and hormonal exposures. A period of testosterone production by the testes, which occurs as ...